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KMID : 0390320200300010001
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Chungbuk Medical Journal
2020 Volume.30 No. 1 p.1 ~ p.8
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Exposure of volatile organic compounds to residents living near Cheongju Industrial Complex
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Im Yu-Jin
Song Myung-Seop
Park Tae-Hyeon
Cho Hyun-Kyu
Lee Jun-Ho
Kim Yong-Dae
Kim Heon
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Abstract
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Objective: Most of the volatile organic compounds (VOC) are fat-soluble, which remain in body to cause a disorder of the nervous system, like benzene, styrene, toluene, and xylene. These chemicals are excreted in human urine as trans, trans-muconic acid, mandelic acid, hippuric acid, and methylhippuric acid, respectively. The purpose of this study is to estimate the level of VOC exposure in residents near the industrial complex and investigate the factors affecting the level of
VOC metabolites.
Methods: Spot urine samples were collected from residents near the industrial complex and residents in control region. Information about demographic characteristics, residence, and history of alcohol consumption and smoking was gathered through a direct survey. The multiple linear regression analysis was used to analyze which factors affect concentration of VOC metabolites.
Results: Mean urinary concentration of trans, trans-muconic acid was higher in current smokers compared to never or ex-smokers. Female showed higher concentration in both urinary hippuric acid and urinary mandelic acid than that of male. Also, subjects living near industrial complex and current smokers showed significantly higher concentration of urinary mandelic acid. Both levels of urinary phenyl glyoxylic acid and methyl hippuric acid were higher in smokers. Education level was another significant factor in analysis of urinary meta-methyl hippuric acid and para-methyl
hippuric acid concentration.
Conclusions: It was shown that smoking as well as education and gender were determinant factors in urine VOC metabolite concentration. Residents living near the Cheongju Industrial Complex were found to have a relatively high exposure to VOCs, especially styrene, compared to those in control area. The results of this study can be used as basic data for the development of an active prevention program for residents living near industrial complex in Cheongju.
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KEYWORD
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Industrial complex, volatile organic compound, general population
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